Multiplex PCR Detection of GSTM1, GSTT1, and GSTP1 Gene Variants
نویسندگان
چکیده
منابع مشابه
GSTM1, GSTT1 and GSTP1 Genetic Variants in Multiple Urologic Cancers.
INTRODUCTION Glutathione S-transferases (GSTs) are phase 2 enzymes responsible for catalyzing the biotransformation of a wide variety of electrophilic compounds, having a crucial role in the detoxification of active metabolites of procarcinogens produced by phase 1 reactions, tying them to glutathione and promoting their excretion in the urine. OBJECTIVES we evaluated GSTM1, GSTT1 and GSTP1 g...
متن کاملGSTT1, GSTP1, and GSTM1 genetic variants are associated with survival in previously untreated metastatic breast cancer
Purpose The polymorphisms in genes including GSTM1, GSTP1 and GSTT1 have been found to predict development and therapeutic efficacy in various malignancies. Breast cancer is one of most common cancers among women. In this study, we evaluated the prognostic value of three functional polymorphisms of GSTs in patients with previously untreated metastatic breast cancer (MBC). Patients and Methods...
متن کاملGSTM1, GSTT1 and GSTP1 Polymorphisms in the Korean Population
The isoenzymes of the glutathione s transferase (GST) family play a vital role in phase II of biotransformation of many substances. Using a multiplex polymerase chain reaction and a direct sequencing analysis, the frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms were evaluated in 1,051 Korean male subjects. We found that 53.8% of the individuals had the GSTM1 null genotype and 54.3% had the...
متن کاملArsenic Methylation, GSTT1, GSTM1, GSTP1 Polymorphisms, and Skin Lesions
OBJECTIVE We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. METHODS A case-control study of 600 cases and 600 controls that were frequency matched on age and sex was conducted in Pabna, Bangladesh, in 2001-2002. Individual well water, urine, and blood samples ...
متن کاملInfluence of GSTM1, GSTP1, and GSTT1 Gene Polymorphisms on Prostate Cancer Risk in Turkish Population
We analysed glutathione S-transferase M1, T1, and P1 gene polymorphisms in a case control study to asses their susceptibility to prostate cancer in Turkish population. Polymorphisms were determined by PCR-based methods in 115 control subjects and 115 prostate cancer patients. The frequencies of polymorphisms were compared between patients and controls by logistic regression analysis. Possible a...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2007
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2007.070030